Description

Your pet must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Heartworm testing is performed annually by your veterinarian to help protect your furry friend. What is Simparica Trio®? Simparica Trio® (Sarolaner, moxidectin, and pyrantel chewable tablets) prevents heartworm disease caused by Dirofilaria immitis, kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations with Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast Tick), Dermacentor variabilis (American Dog Tick), Ixodes scapularis (Black-legged Tick), and Rhipicephalus sanguineus (Brown Dog Tick), and the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonine) and adult hookworm (Anclyostoma caninum and Uncinaria stenocephala) infections for one month. Who is it for? Simparica Trio is for dogs 8 weeks of age and older, and weighing 2.8 pounds or greater. What are the benefits? No messy application Protects dogs against heartworm disease, ticks and fleas, and roundworm and hookworms. Only monthly tick and flea chewable approved to kill 5 types of ticks, including the Gulf Coast Tick. Great-tasting liver flavored chewable that you give your dog once a month. How does Simparica Trio work? Simparica Trio contains three active pharmaceutical ingredients, sarolaner, moxidectin and pyrantel pamoate. Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines. Moxidectin is an endoectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite. Pyrantal pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism. Is there a generic equivalent available? No. How is it given? Simparica Trio is a chewable that is given orally and can be given with or without food. Care should be taken to ensure the dog consumes the complete dose and that part of the dose is not lost or refused. Heartworm Prevention: Simparica Trio should be administered at monthly intervals year-round or at least within one month of the animal’s first exposure to mosquitos and continuing until at least one month after the dog’s last seasonal exposure. Flea Treatment and Prevention: Treatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before fleas become active. To minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with a flea control product. Tick Treatment and Control: Treatment with Simparica Trio may begin at anytime of the year. Simparica Trio should be administered year-round at monthly intervals or started at least one month before ticks become active. Intestinal Nematode Treatment and Control: For the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and adult hookworms (Ancylostoma caninum and Uncinaria stenocephala) infections, Simparica Trio should be administered once as a single dose. Monthly use of Simparica Trio will control any subsequent infections.